Part of me thinks that the Obama administration could reschedule marijuana as something less than a Schedule I drug if they wanted to, and perhaps they don’t want to during an election season. That’s the cynic in me. On the other hand, the correct thing to do is to staff the Drug Enforcement Agency and Food and Drug Administration with professional doctors and scientists and let them make a determination without political interference. At least on the record, that’s what the administration has done. And the result is that marijuana will remain a Schedule I drug just like heroin and LSD.
The Obama administration has denied a bid by two Democratic governors to reconsider how it treats marijuana under federal drug control laws, keeping the drug for now, at least, in the most restrictive category for U.S. law enforcement purposes.
Drug Enforcement Administration chief Chuck Rosenberg says the decision is rooted in science. Rosenberg gave “enormous weight” to conclusions by the Food and Drug Administration that marijuana has “no currently accepted medical use in treatment in the United States,” and by some measures, it remains highly vulnerable to abuse as the most commonly used illicit drug across the nation.
“This decision isn’t based on danger. This decision is based on whether marijuana, as determined by the FDA, is a safe and effective medicine,” he said, “and it’s not.”
This response seems almost impertinent because one of the main concerns about marijuana being scheduled along with highly addictive and dangerous drugs is that it has legal consequences under the Comprehensive Drug Abuse Prevention and Control Act (Act) of 1970. But it’s true that technically the statute requires this scheduling if a drug “has a high potential for abuse and no accepted medical use.” Drugs given the Schedule II designation “have a high potential for abuse but do have an accepted medical use.”
The administration can and in this case has made the argument that there is no accepted medical use for marijuana. I’m not in a better position to judge that than the doctors and scientists. I think there are probably chemical components of marijuana that have medical uses, but they can perhaps be distilled and administered in a more targeted way than simply handing people a spliff and a lighter.
The potential for abuse element of this is a term of art. Obviously, we all know or have known potheads who abuse marijuana to their own detriment. But, to put that kind of abuse on a par with the addictive behaviors of alcoholics and cocaine, methamphetamine and heroin abusers is a total failure of the ability to discern differences in kind and degree.
If I have a problem with the way the DEA and FDA have interpreted the statute, it’s definitely in this “potential for abuse” area. I think they have some leeway to move marijuana off Schedule I based on the fact that it doesn’t create the kind of havoc we see from these other drugs.
Yet, I can see how they would disagree and argue that potential for abuse is potential for abuse, and if Congress wants them to make that kind of distinction then they should amend the law.
Maybe Clinton will put some pressure on for a reconsideration, but it looks like we’ll have to wait for Congress to make the change here so we can stop treating marijuana as one of the most dangerous controlled substances in existence.
We’re already at the point that the Justice Department doesn’t want to continue to treat marijuana as prosecutable drug, so it would be nice if we could get the law to reflect that somehow rather than perpetuating this situation where a bad law is dealt with by pretending it doesn’t exist.
And, of course, they don’t always pretend that the law doesn’t exist, so we wind up with selective enforcement which is arbitrary and undermines confidence in the rule of law.
I wish the DEA had come down differently, but I can’t quibble too much with their decision, as the greater sin is politicized science.
So, how long before Congress gets its act together?
I was under the impression that only Congress could reclassify a drug. That they did so under advice from the FDA, but that they alone had that power.
At this point it looks like “When hell freezes over” or “After the collapse”.
Even granting that Democratic control of Congress might unblock the logjam, they might race down the same paths that Republicans have trod on this issue and others. But they will deliver legislation. Just not terribly good and oft compromised legislation.
If they are going to take that argument with marijuana, why not classify alcohol as a Schedule I drug? I think we’ve had experience with that policy before and there are two Constitutional amendments concerning it.
As for the professionalism of the FDA and DEA, the bias toward fast-tracking Big Pharma’s lastest creations has led to several instances of grief in the past few years. And marijuana has dramatically more studies and metastudies and clinical studies of its properties, action, and side effects than a whole lot of the fast-tracked pharamaceuticals that also have psychotropic properties or side effects. And also are subject to abuse.
What we have here is the intent to keep an excuse for law enforcement in being, law enforcement that was conceived in the inter-war era specifically for its ability to give blacks criminal records.
Political demagoguery is what politicians fear and why they have not moved on this. Even in states that have decriminalized marijuana use by referendum, the politicians’ positions and that of law enforcement are unchanged in the face of the fact that their dystopian predictions have not come true.
Yes, it was a cynical move in an election year. but might have the result of more voter turnout in states with marijuana referendums, and that can also be spun as a cynical move. But what it doesn’t do is hype up voter turnout of those who favor prohibition.
Upton Sinclair was channeling lo those many years ago – “It is difficult to get a man to understand something, when his salary depends upon his not understanding it!”
Duh, BIG Pharma has a vital interest in keeping it Schedule I. Use of opioid painkillers drops with use of mj. What is the size of that market?
http://www.crescolabs.com/prescription-opioid-abuse-rates-drop-in-medical-marijuana-states/
And no, taking individual extracts and patenting them is NOT the way to go. Synergy.
And that’s where your inner cynic needs to turn, not to election year bullshit. The DEA has an institutional prerogative to keep any reform off the table. Domino effect: we start looking to actual ways to treat these drugs as a health issue, why even have a DEA?
And then the FDA cynicism is where your quote comes in. It’s not acceptable as medicine until we can separate the chemicals (read: commoditize and monetize) of the drug into a pill or dosage form.
Again, mj legalization in Colorado (a swing state) got more votes than did Obama to the tune of 70,000. This was enough for the measure to win 55%; Obama got 51%. Romney got more votes than did “no” (70,000 difference here). So right there, the issue was more popular than Republicans and Democrats. In Washington, Obama got slightly more votes, but not much — 30,000, or about 0.4%.
Cannabis shops in Oregon and Washington sell a variety of extracts, with statements on the label about the percentage of the compounds thought to be medically beneficial.
Yes, but what does that even mean? It gives a THC content, generally. Now how is a doctor supposed to prescribe that, know how much should be prescribed for the respective ailment, and so on? Until that comes to fruition, the FDA is going to continue saying there’s no evidence of medical benefit.
For my own anecdotes, I know of someone who suffers from fibromyalgia. She takes Lyrica on a regular and daily basis (Lyrica is also very very expensive) and it allows her to manage the pain day to day. But there are times when she has “flares”, nothing works really (traditional pain meds don’t help fibromyalgia), and the pain is so debilitating that she has trouble working or sleeping. What works? Marijuana. No pain. None.
To the extent that fibromyalgia is an inflammatory disease, there is a new field called functional medicine that might deal with it better than painkillers. One of the leaders in this field is Dr. Mark Hyman of the Cleveland Clinic.
And for the prohibitionists, they should be moving to looking at that instead of wasting time opposing reclassification of marijuana.
Indeed, there needs to be scientific review of the entire schedule because some drugs were just grandfathered into their positions without attention to subsequent research.
Big Pharma’s oligopoly profiteering has truly incapacitate many people who cannot afford the prescribed regime of doses. Aside from the marketing of drugs for other conditions without adequate testing.
I found this decision just a little too prim and proper and dismissive. That is, it is a political, not a scientific decision.
The fact that THC is the listed ingredient tells something about the usage of these extracts. The evidence for cannabidiol (CBD) having medical benefits is better than that for THC. THC, on the other hand, is far more psychoactive.
Sure, and fine. But that doesn’t address the issue. How much, of what percent, and for which ailments should the respective chemicals in the drug be prescribed.
Hey we know this high CBD oil helps your kid with her seizures. Keep taking it. But I couldn’t tell you where that threshold of “high CBD oil” helps, where it doesn’t, how much is too much. It’s all trial and error at this point. And that isn’t going to hold much sway at the FDA.
I see CBD listed on cannabis products in Oregon.
I’ rather have a spiff and a lighter than a boring pill that basically strops the potential for chillin out of taking it.
I know we shouldn’t go making policy based on anecdote, but I have seen marijuana work for a medical condition first hand. One of my good friend has a teenage son with the type of epilepsy that sends you to the ER and can, if left untreated send you to the morgue. Marijuana has been a boon to them. It hasn’t cured his epilepsy, but what is has done is allow them to back off enough on the pharmaceuticals that he is no longer a zombie that stays in his bed for 20 hours per day.
The DOJ is using a pretty narrow definition here. Marijuana definitely has antiemetic, analgesic medical uses. However, there are isolated endocannabinoids (synthetic and natural derivatives) that have been developed for those purposes. It’s an open question as to how efficacious those drugs actually are, but that’s where we stand today.
I’m a little disappointed by this development, albeit completely unsurprised.
Correcting a mistake: meant to write cannabinoids. Too much medical literature on the brain. Endocannabinoids are, by definition, the ones that are synthesized naturally in the body.
I’d say this sort of observation is as valuable and valid as an observation made by a guy in a white lab coat.
single “observation made by a guy in a white lab coat”?
OK, sure.
As “valuable and valid” as conclusions of statistically significant effects in data derived from a controlled clinical study?
Um, no, not so much.
It’s extremely helpful in swaying public opinion, even if it’s not useful in the lab. It’s why Sanjay Gupta did what he did, with an about face on the issue by seeing for his own eyes people with chronic illness or pain who now have some relief for the first time in their lives. And when the drug has not caused any recordable death simply for taking the drug, it’s very hard to look these people in the eye and tell them you’re going to deny them that relief.
relevant clinical studies haven’t been done), then anecdotal evidence is all you got.
And it may be better than nothing. (For example, if someone is qualified to apply some relevant expertise to interpretation of the anecdote[s]. Seems Gupta thought he was*.)
OTOH, it may be worse. Far worse. Think Jenny McCarthy and anti-vaxxers, with their reliance on anecdotal “evidence” (still; even after the sole purportedly “scientific” study supporting them was exposed as fraudulent and formally withdrawn by the journal that had published it); or any other case in which the anecdote may be an outlier, leading to a conclusion very different from — even opposite to — what a clinical study would have found. So while an anecdote may be “helpful in swaying public opinion”, that can be a very, very bad, harmful thing.
And whether or not the anecdote is “useful in the lab” completely misses the point, which isn’t whether or not that’s true, but which — anecdotes or evidence from clinical trials — is more “valuable and valid” for informing and shaping law, policy, and practice. There can be no serious dispute about the answer to that.
The post I responded to seemed dismissive of those “guy[s] in white coat[s]”. In fact what they contribute is critically important.
*Not a fan. I recall too well the silly feud he instigated with Michael Moore over Sicko. Short version: he said on air Moore got some things wrong (or words to that effect). Moore responded hunh-unh, no I did not, and provided evidence in support of the points Gupta had called wrong that was, at a minimum, at least credible. Gupta “argued” this by pointing at other evidence that could be interpreted to lead to a somewhat different conclusion (with the differences fairly trivial, as I’m recalling it now).
Paid science and regulatory capture is putting question marks on those white lab coats.
And it is very well documented. Everything gets corrupted when profit is king.
Science isn’t perfect (duh, it’s done by human beings!).
What science gets done depends on what research someone is willing to fund. “Paid science” is in practical terms all that exists. The days of 18th-Century leisured nobles pursuing “pure” science driven only by personal interests and curiosity are gone with . . . well . . . the 18th Century! Scientists don’t work for free, nor should they; nor is it reasonable for anyone to expect them to.
I almost included in the previous comment (decided it was already long enough as is, and this could be addressed if it came up): one reason clinical studies on marijuana effects are sparse to non-existent is probably that a large chunk of medical research gets funded by Big Pharma, and Big Pharma funds the research in which they see profit potential, not primarily for its humanitarian benefit (think others have already pointed this or something close to it out in this thread).
Government-funded research (NSF, NIH, etc.) provides at least some counter-balance for this, but competition is fierce for those grants, and potential “practical” benefits/applicability tend to boost the competitiveness of a proposal in reviewers’ eyes.
All that acknowledged, science remains the best means we have of discerning and understanding discernible Reality, so far ahead of whatever anyone might suggest for second place as to be in a class by itself. In large part thanks to the built-in mechanisms (e.g., peer review, replication of results) that make it self-correcting over time. (For a very relevant example, that fraudulent study the anti-vaxxers latched onto was exposed and refuted through the normal procedures of science, the equivalent of “regular order” in legislative parlance.)
I’d be very happy to see my fellow lefty/liberals leave the anti-science attitudes and demagoguery in the capable (for that) hands of the wingnuts. They’re working hard to corner that market anyway. Let’s let them!
Blanket acceptance is just as bad and unreasoning, imo. It’s a damn serious problem.
Check the bonafides of studies. Who is paying for the science and WHO is reviewing/critiquing it?
“Dr. Marcia Angell, a physician and longtime Editor in Chief of the New England Medical Journal (NEMJ), which is considered to another one of the most prestigious peer-reviewed medical journals in the world, makes her view of the subject quite plain:
“It is simply no longer possible to believe much of the clinical research that is published, or to rely on the judgment of trusted physicians or authoritative medical guidelines. I take no pleasure in this conclusion, which I reached slowly and reluctantly over my two decades as an editor of the New England Journal of Medicine”
http://www.collective-evolution.com/2015/05/16/editor-in-chief-of-worlds-best-known-medical-journal-
half-of-all-the-literature-is-false/
Also…
Vol 385 April 11, 2015
Richard Horton (Ed-in-Chief)
Offl ine: What is medicine’s 5 sigma?
“A lot of what is published is incorrect.” I’m not allowed to say who made this remark because we were asked to observe Chatham House rules. We were also asked not to take photographs of slides. Those who worked for government agencies pleaded that their comments especially remain unquoted, since the forthcoming UK election meant they were living in “purdah”–a chilling
state where severe restrictions on freedom of speech are placed on anyone on the government’s payroll. Why the paranoid concern for secrecy and non-attribution? Because this symposium–on the reproducibility and reliability of biomedical research, held at the Wellcome Trust in London last week–touched on one of the most sensitive issues in science today: the idea that something has gone fundamentally wrong with one of our greatest human creations.
The Lancet…http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736%2815%2960696-1.pdf
counseled “blanket acceptance”. Also acknowledged imperfections along the lines your links illustrate.
They don’t incline me to withdraw this, though:
Would you disagree? If so, what means of discerning Reality would you put ahead of science?
I would also consider the statements you link part of the self-corrective process I referred to, though extreme examples, and it’s certainly plenty disturbing that the authors felt driven to step outside the more-usual procedures for such correction.
Also seems noteworthy that your examples are from medical research, which seems (though it’s not my field) to have greater problems in these areas; which I’m pretty inclined to attribute to the aforementioned problem that a big chunk of the medical research that gets done gets done because it’s funded by Big Pharma based on perceived potential profitability.
Due diligence. See a LOT of online bullying from science absolutists who believe everyone who has reservations or oppostion is an automatic anti-vaxxer.
And the five yr rule for pharmaceuticals.
seems most salient to me right now isn’t anti-vaxxers, it’s climate- (hence science-)denialism. Which follows in direct lineage, and shares all the methods of, tobacco-company “science” before it.
Just a friendly note: what you wrote is completely bullshit
Sorry, see below. No intention to be dismissive.
Yes, of course. I do scientific research (sans white lab coat) myself. I guess I’m remarking about the tendency of medical professionals to disregard anecdotal evidence.
no substitute for controlled study.
Er, and the tendency to treat unproven nostrums as scientific absolutes?
Like hormone replacement for women?
I’m not totally clear on this; are you referring to the 2002 women’s health initiative study? Because there have been many other studies since that have come to an entirely different (if not the opposite) conclusion. I haven’t thought about this stuff since graduate school but frankly it seems like controlled studies with narrower patient groups have refined our understanding of HRT and its safety. In any event, there were never any “unproven nostrums” re: HRT. Its efficacy in treating osteoporosis (for example) has been known for 25 years now.
Did you happen to read the rapid response that is linked in the article….http://www.bmj.com/content/345/bmj.e6409/rapid-responses
Just reading the parameters, it did not seem well designed and many commenters agreed with me. Even the authors admit “the power of the study is low.” It piggy-backed on a different study, the DOPS.
Another was bothered enough by the hyping of this study to post a crit while on vacation… And here you go: “This study ended years ago and is now just getting published. Why? Were the authors playing with the data? The study was industry funded and the authors have industry ties. Hmmm.” https:/ebmteacher.com/2012/10/20/danish-osteoporosis-prevention-trial-doesnt-prove-anything
Are you familiar with Dr. John Ioannidis and meta-research? http://www.theatlantic.com/magazine/archive/2010/11/lies-damned-lies-and-medical-science/308269/ A very well-respected critic of today’s state of affairs.
I am very familiar with John Ioannidis. I am also a regular reader of retraction watch (Marcus, Oransky).
It’s definitely true that clinical studies have a reproducibility issue. Even worse than your typical high impact research. I think this problem has less to do with financial conflict of interest and a lot to do with perverse publishing/funding incentives.
As her record on same-sex marriage proves, Clinton will support sanity in marijuana law the day it becomes less politically costly than the alternative and not one millisecond before.
A few more state referenda might do the trick.
She’s no different from other politicians, just more sensitive that some other politicians get passes that she does not.
So she’s supported legalized cannabis for a few years now?
Good.
This is the last wall of the castle.
When marijuana becomes legal in California there will have to be adjustments made to the federal law. There was an eighteen year-old here in Oregon who was facing a year in jail for possessing a gram of grass. The federal prosecutor had a wild hair up his/her ass. My congressman and our two senators stepped in, had a heart to heart, and the feds backed down. A conviction would have seriously screwed up the remainder of the kid’s life. For what? I live just off a street that is called The Green Mile because of all the marijuana shops that have opened in the last year and a half. It’s really remarkable, all the small businesses springing up. Crime? The major problem is that marijuana businesses have a curious status with the feds, and so federal banking laws prevent marijuana sales from using banks. That means that it’s a cash-only business, and that means that the biggest problem is punks robbing stores for the money. As far as public intoxication, it’s not any worse than it has been, and almost all of it is caused by alcohol. If anything, people spend more time at home or sitting on their front porches chatting to neighbors.
It’s all pretty ironic, considering how many big banks seem to have no concerns about moving around real drug money.
So I expect that the feds will make some adjustments when California goes on line. I expect this in spite of Clinton’s most likely election. Clinton would make a lot of enemies by sticking firm to the stupid Harry Anslinger way of doing business.
As for Obama, he’s proven he’s not a trendsetter, and he sees no political gain at this stage of his presidency to loosen up marijuana laws.
The Green Mile? Hadn’t heard that term, Bob, but would that be NE Sandy Boulevard? I live a few blocks off Sandy and yes, there are more cannabis shops in the vicinity than you can shake a stick at..
We have banks in Colorado. The Feds will let banks do business with weed businesses as long as they’re not a cover for illegal activity. The key thing is that the onus is on the banks to verify this, making it fairly expensive and difficult for banks to do. That said, as more companies make millions in legal weed, there is more and more incentive for local banks to get in the game. For clarification on the legal status of cannabis related businesses and banking, google “DOJ Cole memo.” It’s actually a pretty enlightened policy.
Aren’t there more important things to talk about right now?
Our impending war of regime change against Syria, which will almost certainly bring us into military conflict with the world’s second largest nuclear power, is certainly a more urgent topic.
But somehow I get the feeling that wasn’t what you had in mind.
I’m fairly pessimistic about HRC’s foreign policy but I’ve seen nothing yet that indicates we’re headed for a direct confrontation with Russia over Syria. She is a hawk but also rational. Military conflict with a nuclear power isn’t rational.
Getting rid of Assad isn’t worth it and the primary priority is ISIS.
That’s why Obama, in my opinion, has been able to resist escalation despite the whining from the neocons and liberal interventionists. My hope is that talks with Russia over the next few months lead somewhere that will tie HRC’s hands with regards to her instincts for making foreign policy errors.
However… there is a problem with regards to Ukraine. There are reports of a Russian build-up in recent days and if there’s an incursion all bets are off as to how Washington responds and it could affect other areas.
Secondly.. interference in the election will certainly worsen relations as I doubt HRC will be quick to let it go once in office.
One might argue that hawkishness is inherently irrational.
What would be the point of that argument? By that standard you couldn’t name a non-hawkish President going back a hundred years.
No.
Nope.
There’s not a single more important thing in the universe to discuss right now.
Please fax me a list of all the more important things so I can get to them all before I sin again.
I’m a liberal on most things and was once on this too. But living in Washington state, I’ve seen how first medicalization and later legalization have had negative impacts. For one thing, places where shops open become hangouts for some pretty scary people. I wouldn’t want one near my home.
There may be benefits too. There’s of course much to a thorough analysis. It’s possible that with time I’ll change my mind again if there are positive impacts that outweigh the negatives. But at the surface, I’m not liking what I see.
Interesting observation about cannabis shops becoming “hangouts for some pretty scary people.” I haven’t noticed that at all in Portland. There’s one cannabis shop a few blocks from my home that I walk past a few times a week, and I’ve never seen anyone hanging out there. Just an example.
I don’t see anything like that in Portland. In fact, we were at one shop in the mid-afternoon one day and everyone in the place was of social security age.
By the way, my life partner/girlfriend/main squeeze uses an ointment with high CBD content for pain and it works for her. And me. There are somewhere over a hundred different cannabinoids in marijuana and most research so far has been limited to THC and CBD, so more research really needs to be done. Meanwhile, CBD has been shown over and over to have painkilling properties (not getting high properties, though). THC allows for enjoyment of the most ridiculous offerings TV has.
Say more about “scary people”. That is a strange observation about a shopping area.
Scary people? I live in Oregon, drive past a dozen marijuana shops every day (2 within a quarter mile of my home), and have seen nothing of the sort.
You want to see scary people? Drive on the freeway, I see scary people there every day.
and under the freeways?
I left a few years back (right after legalization) but I recall pot dispensaries in WA state as being in shitty locations, like frontage roads, etc. They are undoubtably restricted by stringent zoning laws, so you’ll probably never have to worry about living next to one.
There are marijuana stores all over Portland. There is no such thing as bad types loitering around them. There are new gardening stores set up for growing marijuana, hydroponics stores, etc. Places that had closed storefronts are now full.
In fact, I’m trying to think of any incidents around any pot stores and I can’t think of any besides the occasional robbery, and that’s due to banking laws and it being a cash business, although even then most stores have pretty good security for both the product and the cash.
There was a guy who was beating up a woman and threw someone through a plate glass window in our neighborhood but that was a sports bar. You know, alcohol.
I suspect, from many of the comments and concerns, that people who fear legalization really don’t have much history with marijuana, and the whole argument about its dangerousness is uninformed and silly. Marijuana does not make people aggressive. People who are aggressive occasionally smoke marijuana. People who are criminals occasionally smoke marijuana.
Marijuana appears to have some medical properties, and hopefully in the future the government will stop being stupid about it, but it doesn’t make people crazy.
Also too, you rightly lump alcoholics in with other addicts.
Which is where it becomes obvious that the current situation not only makes no sense, it’s ridiculous. Think the case is very strong that alcohol has not only potential for abuse, but is already very widely abused, causing immense societal harm and cost (on the order of 30K traffic fatalities caused by impaired drivers every year, just for starters), that’s far greater than pot use/abuse causes now or even could be expected to cause if decriminalized nationally.
That pot’s schedule I and alcohol sales to adults are essentially unregulated nationally is absurd on its face from that standpoint, regardless of legal technicalities and constraints on DEA/FDA (though you’re right that they are constrained by the law and science; and that thus the law as written is the problem).
I was also under the impression that a number of medical professional groups had in fact concluded that marijuana does have legitimate therapeutic uses, including for some patients who are not helped by other available treatments; and that this has been the driving argument for medical marijuana legalization in some states, like here, though this puts patients and providers in jeopardy, since it’s still Schedule I under Federal law. In fact, I had the impression that issue had been pretty much resolved in favor of legitimate medical uses, to the point of it being “case closed” by now. So the “no accepted medical use” finding seems surprising and pretty arguable.
One thing about medical marijuana that is legitimate cause for concern is the fact that nobody has a clue about how it interacts with other pharmaceuticals. Yes, you can cynically (and perhaps correctly) state that the reason nobody has a clue is the power of Big Pharma, but the lack of knowledge about drug interactions remains. I happen to know someone who was told by his doctor not to use cannabis for chronic pain because of the unknown potential for drug interactions.
Honest question: how much do we know about how most drugs interactions with most other drugs? I know we have solid knowledge about some (alcohol and barbiturates, and lots of other things), and good knowledge about how some types of drug actions are likely to have problems with other types of drug actions.
But in terms of measuring each drug against every other drug? That seems mathematically impossible.
So what’s lacking here? Is it that we do not understand what type of drug interaction Cannabis has so we can’t make guesses about how it will interact with other drugs?
In terms of lethality Cannabis is remarkably safe, safer than nearly every other drug. So have there been any dangerous drug interactions with Cannabis identified at all?
I know back in the day I couldn’t handle the stuff if I had been drinking…
What does ‘couldn’t handle the stuff’?
Nothing too tragic, get dizzy and have to lie down mostly. Some times the lie down was a bit sudden.
Heck, they aren’t require to warn against gender and age effects, either. A 70yr old 100# female gets same dosage as 200# 35 yr old male?????
There are always surprises with medicine. Grapefruit juice has an enormous effect on drug bioavailability. This was only discovered in 1991 (and fully appreciated a few years later), long after the advent of modern medicine, and certainly long after the development of grapefruit juice. The discovery was made entirely by accident — we still might not know about it if researchers hadn’t chosen a particularly strongly flavored carrier to mask the taste of alcohol that the drug (felodipine) was dissolved in.
There HAS been research on the major aspect–pain relief…
Chronic pain is the leading indication for medical cannabis use, accounting for 90% of the patients in Oregon’s medical marijuana program. More than 60 studies have shown cannabinoids to be effective in pain relief, according to a compilation by the International Association of Cannabis Medicine which includes four controlled studies of smoked marijuana by California’s Center for Medicinal Cannabis Research.
Studies indicate that cannabis interacts synergistically with opioids in such a way as to improve pain relief [1, 2]. California medical cannabis specialists consistently report that patients are able to reduce use of opioids -typically by 50%- when they add cannabis to their regimen.
Cannabis can therefore be seen as a gateway drug leading away from opioid addiction.
http://www.canorml.org/prop/PainClinicsOShaugh.htm
Why is “chronic pain” so much more prevalent in the US than other western countries?
With legal access to mild pain relievers and stimulants and anxiety reducers, that’s what people prefer to use and only seek medical treatment if the legal stuff is insufficiently effective. Doesn’t mean the legal stuff can’t be abused and create dependencies and a variety of other negative consequences. Only that on balance, the aggregate societal harm is less than that of any manageable alternatives.
Enough is known about marijuana that legalizing it is safe enough for adults.
A functional medicine practitioner would say what makes chronic pain more prevalent in the US is the standard American diet that also makes Americans more obese than citizens of other western countries.
I’m going to pass along the functional medicine recommendation. Thank you.
Is chronic pain more commonly reported in the US than elsewhere? I did not know that. I do realize that there can be cultural factors at play in diagnoses.
Anyway, there are people in my life–personal and professional–with chronic pain. And I’ve had the hellish experience of a herniated disc and associated referred pain, so I empathize.
There was a study done in 2008 published in the Journal of Pain (Tsang et al) that found that the US was not unique in terms of chronic pain among the 16 other developed and developing countries surveyed.
Actually, if you have a heart to heart with your doctor, and your doctor isn’t a dick, they are generally pretty honest about using grass with other drugs. My partner needed two back surgeries, and all the painkillers they gave her during the process, up to and including morphine, weren’t very effective, plus they all made her nauseous. Not marijuana. It’s not going to replace general anesthesia, but it does help tremendously.
The fact is the more marijuana she smoked, ate or rubbed on herself, the less she had to use opioids. Much healthier.
Well, in the case of the friend I referred to, the doctor’s response to being asked about marijuana was that the friend would have to agree to consent to random drug tests, otherwise the prescription for painkillers would end.
You would think doctors would be eager to reduce opioid prescriptions. They can get in real trouble with licensing boards over their usage.
Random drug tests? The doctor was going to force random drug tests on a patient he’s prescribing opioids to to see if he had marijuana in his system?
That suggests that the doctor doesn’t know what the hell he’s doing and knows nothing about marijuana, which is really sad.
The general course for people I know is to avoid the subject in case their doctor is like your friend’s doctor. But, as I said, neurosurgeons taking care of my girlfriend’s back surgery thought it was great that she got relief from pain without opiates.
TBH, allowing researches to study the drug will help combat my biggest fear which is the unchecked influence of a poweful Big Weed lobby.
“Big Weed Lobby” and the few that will become extremely wealthy over the years of legalization is also a concern of mine. But research on MJ will have zero impact on the MJ biz. We have a perfectly well developed regulatory apparatus for both alcohol and tobacco. No need to reinvent the wheel. Just add few tweaks to maximize growers’ income and prevent monopolies throughout the distribution chain.
Somebody’s going to make money on it. But at least with the laws out here in Oregon people are allowed to grow their own, which will be a brake on runaways profits. I think everyone on our block has a few plants growing in the backyard. The cost of marijuana has been pretty constant (and a lot lower than buying it from an illegal dealer). The few changes in price are more a reflection of local and state taxes being jiggled up and down and not of the product itself.
As far as business opportunities, as I’ve said elsewhere there are plenty of small weed stores all over the city. A friend of mine, who’s a graphical designer, is making professional packaging for marijuana suppliers. It’s an expanding business, and a lot of people are getting in on the bottom.
Will tobacco companies try to horn in on the business. I’m sure some will try. I’m not sure they can corner the market. Unlike having a still in your backyard, growing marijuana is the easiest thing you can do. You stick a seed in the ground and water it.
Yes, we tend to favor monopolies and that is one heck of an income stream to be swallowed.
Watch out for take-overs and market consolidation. And the push to patent.
Mj as non-prescription, non-Schedule is optimum. It’s a damn sight safer than OTC Tylenol.
Branding and availability does the trick without patents. At least through almost all of the product life-cycle. There’s a lot more consumer awareness about pesticides, GMOs, sustainable agriculture, and the homogenization of products then in the past. Particularly among younger people. Will be harder to replicate the “this Bud’s for you” market success with a weak product. As marijuana is mostly a discretionary item, government does have a role to play maximizing choice and that in turn helps to minimize the emergence of monopolies (that are inherent to the model of capitalism). And sometimes, when one good or service is so far superior to all the others that it comes to dominate the marketplace, government still has a role to play by making it a regulated monopoly.
Thing is, they’re already pressing for no rules or standards at all so they can pocket money. Having hard data will help in the fight to design common sense regulation.
The Big Weed lobby already exists. Its current product line is tobacco. Many of the corporations have also added food to their product lines.
A good retro read on this turn of events in Max Schulman’s Anyone Got a Match? (1964).
It is easy to say that there are no studies proving that cannabis has therapeutic uses when conducting those studies in the U.S. has been illegal.
ding ding ding
At least the DEA tolerates basic science in cannabinoids. And tolerate is probably the best term for it.
I can’t say how strongly I disagree with this ruling. I literally moved to Colorado for a job in this industry, and it has A) been very good for me, and B) obviously not made Colorado fall apart at the seams. Furthermore, I have friends here with MS and epilepsy who swear by the results they get, and I have met people with chronic pain issues that have completely kicked opiates. All of this from, as you say, spliffs and lighters. If there is someone feeling threatened here it is the big pharma companies that are worried the profits from their patented medications (that often fall short of promised benefits and/or have serious side effects) will evaporate as people figure out this plant is medicinal.
And in terms of abuse, sure, whatever. People do abuse this, but they abuse their smart phones, too, and this doesn’t lead to hardcore addiction like meth or heroin, and there are literally millions of well-functioning recreational users around the country who go to work, do their jobs and treat their families well.
This ruling is nothing short of a travesty that does nothing but hold back scientific and economic progress. I’m not worried, though. We’re winning and we have been for years. Sooner or later mainstream Democrats will wake up and smell the political benefits of backing ganja. It’s only a matter of time.
I wish the DEA would reschedule psylocibin and LSD, that THC is kid stuff and they all fucking test for it. Still waiting for that solid gold commode as well…probably gonna be a while.